Celiac disease
Cow’s milk protein allergy
Hemolytic uremic syndrome
Inflammatory bowel disease
Toddler’s diarrhea

  • Describe the pathophysiology of osmotic and secretory diarrhea
  • Classify diarrhea based on the underlying pathophysiological mechanisms
  • Recognize that some forms of diarrhea are manifestations of systemic illness

Overview & Foundational Knowledge

First Principles of Gastroenterology. The basis of disease and an approach to management. Fifth edition. Chapter 14. Manifestations of Gastrointestinal Disease in the child. Page 710-719.


Textbook chapter. Review on acute diarrhea and dehydration

Penelope H & Dennehy MD. Acute Diarrheal Disease in Children: Epidemiology, Prevention, and Treatment. Infectious Disease Clinics of North America 2005; 19: 585–602.

Overview article on gastroenteritis.

Granado-Villar D, Cunill-De Sautu B & Granados A. Acute Gastroenteritis. Pediatrics in Review 2012; 33: 487.

Overview article on treatment of gastroenteritis and dehydration.

Zella GC & Isreal EJ. Chronic Diarrhea in Children. Pediatrics in Review 2012; 33: 207-218.

Overview on chronic diarrhea. Comprehensive differential diagnosis.

Corrigan Jr JJ & Boineau FG. Hemolytic-Uremic Syndrome. Pediatrics in Review 2001; 22: 365-369.

Brief review on hemolytic uremic syndrome. Not essential but good review.

Hyams JS. Inflammatory Bowel Disease. Pediatrics in Review Vol. 26 No. 9 September 1, 2005, pp. 314–320.

An overview of IBD with a focus on differential diagnosis, presenting features as well as an overview of medications for IBD.

Vandenaplas Y et al. Guidelines for the diagnosis and management of cow’s milk protein allergy in infants.  Archives of Disease in Childhood 2007; 92: 902-908.

Includes algorithms for formula and breast fed infants.

Clinical Resources

Dehydration and Diarrhea



Parental handout on gastroenteritis, available in English and French.

Oral rehydration therapy and early re-feeding in the management of childhood gastroenteritis



Canadian Paediatric Society Position Statement (2006). Clinical resource on treatment of dehydration.

Virtual Patients or Cases

Dehydration. University of Alberta Pedscases.



Audio podcast of an approach to assessment and management of dehydration (20min).

Clinical Presentations