Neonatal Jaundice

Biliary atresia
Breast feeding jaundice
Breast milk jaundice
Hemolytic anemia
Physiologic jaundice

  • Describe liver anatomy and the physiology of bilirubin metabolism and excretion
  • Describe the functions of the liver and interpret tests of liver function, hepatocellular function and cholestasis
  • Differentiate between conjugated and unconjugated hyperbilirubinemia
  • Describe blood group type and antigens, and explain the mechanism whereby blood group incompatibility can affect bilirubin metabolism

Overview & Foundational Knowledge

Bryon J. Hyperbilirubinemia in the Newborn. Pediatrics in Review 2011; 32(8): 341-349.

Some foundational knowledge on bilirubin metabolism. Discusses physiologic versus pathologic hyperbilirubinemia. More focus on unconjugated hyperbilirubinemia (e.g. breast milk and breastfeeding jaundice).

Brumbaugh D & Mack C. Conjugated hyperbilirubinemia in children. Pediatrics in Review 2012; 33(7): 291-302.

Foundational knowledge. Addresses cholestasis in newborns and older children. Addresses the importance of early diagnosis in newborns. Good visuals.

Clinical Resources

Guidelines for the detection, management and prevention of hyperbilirubinemia in term and late preterm newborn infants

Canadian Paediatric Society Position Statement (2007, 2011)

Clinical Presentations