Pallor / Anemia
Hemolysis
Iron deficiency anemia
- Describe the anatomy and physiology of the hematopoietic system, including origin, function and structure of each major blood component
- Describe iron metabolism as it relates to heme production
- Classify hematologic disease in terms of production, destruction and consumption
- Describe the physiologic consequences to anemia
- Identify signs and symptoms of hematologic diseases
- Demonstrate an approach to the interpretation of a CBC and differential and iron studies
Overview & Foundational Knowledge
| Acquired and Congenital Hemolytic Anemia
https://doi.org/10.1542/pir.2015-0053 Suzie A. Noronha, MD. Pediatr Rev (2016) 37 (6): 235–246. |
| Janus J & Moerschel S. Evaluation of anemia in children. American Family Physician 2010; 15(12): 1462-1471.
http://www.aafp.org/afp/2010/0615/p1462.html Good basic article with flow diagrams capturing diagnosis based on age and MCV. |
| Thalassemia
https://www.ncbi.nlm.nih.gov/books/NBK545151/ Hamza Bajwa; Hajira Basit. StatPearls |
Clinical Resources
| PedsCases: Anemia
https://www.pedscases.com/approach-anemia One page summary on Anemia |
| PedsCases: Sickle Cell Disease
https://pedscases.com/sickle-cell-disease-overview One page summary on Sickle Cell Disease |
| Acute complications in children with sickle cell disease: Prevention and management
https://cps.ca/en/documents/position/acute-complications-with-sickle-cell https://cps.ca/fr/documents/position/complications-aigues-de-lanemie-falciforme CPS Position Statement (2022) |
| Iron requirements in the first 2 years of life
https://cps.ca/documents/position/iron-requirements https://cps.ca/fr/documents/position/les-besoins-en-fer CPS Practice Point (2019) |
Virtual Patients or Cases
| PedsCases podcasts on Anemia (2 parts) |
Cards
| Pallor / Anemia
Canuc-Paeds physician authored, replayable cases |
